Pesquisa | BVS Violência e Saúde

1.

Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.

Johnson, Carl Hirschie; Egli, Martin.

Annu Rev Biochem ; 83: 221-47, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24905782

2.

First prediction of sequence-specific recognition of double-helix nucleic acids by proteins.

Egli, Martin; Zhang, Shuguang.

Nat Rev Mol Cell Biol ; 23(3): 166, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35022569

3.

How the α-helix got its name.

Egli, Martin; Zhang, Shuguang.

Nat Rev Mol Cell Biol ; 23(3): 165, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35075297

4.

Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency.

Egli, Martin; Schlegel, Mark K; Manoharan, Muthiah.

RNA ; 29(4): 402-414, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36725319

5.

Chemistry, structure and function of approved oligonucleotide therapeutics.

Egli, Martin; Manoharan, Muthiah.

Nucleic Acids Res ; 51(6): 2529-2573, 2023 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-36881759

6.

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.

Tomar, Rachana; Minko, Irina G; Sharma, Pankaj; Kellum, Andrew H; Lei, Li; Harp, Joel M; Iverson, T M; Lloyd, R Stephen; Egli, Martin; Stone, Michael P.

Nucleic Acids Res ; 51(8): 3754-3769, 2023 05 08.

Artigo em Inglês | MEDLINE | ID: mdl-37014002

7.

Hiding in plain sight: three chemically distinct α-helix types.

Zhang, Shuguang; Egli, Martin.

Q Rev Biophys ; 55: e7, 2022 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-35722863

8.

Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase Î·.

Tomar, Rachana; Li, Songlin; Egli, Martin; Stone, Michael P.

Biochemistry ; 63(6): 754-766, 2024 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-38413007

9.

The peroxidation-derived DNA adduct, 6-oxo-M₁dG, is a strong block to replication by human DNA polymerase Î·.

Richie-Jannetta, Robyn; Pallan, Pradeep; Kingsley, Philip J; Kamdar, Nikhil; Egli, Martin; Marnett, Lawrence J.

J Biol Chem ; 299(8): 105067, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37468099

10.

Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure.

Harp, Joel M; Lybrand, Terry P; Pallan, Pradeep S; Coates, Leighton; Sullivan, Brendan; Egli, Martin.

Nucleic Acids Res ; 50(13): 7721-7738, 2022 07 22.

Artigo em Inglês | MEDLINE | ID: mdl-35819202

11.

Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.

Jahns, Hartmut; Taneja, Nate; Willoughby, Jennifer L S; Akabane-Nakata, Masaaki; Brown, Christopher R; Nguyen, Tuyen; Bisbe, Anna; Matsuda, Shigeo; Hettinger, Matt; Manoharan, Rajar M; Rajeev, Kallanthottathil G; Maier, Martin A; Zlatev, Ivan; Charisse, Klaus; Egli, Martin; Manoharan, Muthiah.

Nucleic Acids Res ; 50(3): 1221-1240, 2022 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-34268578

12.

From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.

Schlegel, Mark K; Janas, Maja M; Jiang, Yongfeng; Barry, Joseph D; Davis, Wendell; Agarwal, Saket; Berman, Daniel; Brown, Christopher R; Castoreno, Adam; LeBlanc, Sarah; Liebow, Abigail; Mayo, Tara; Milstein, Stuart; Nguyen, Tuyen; Shulga-Morskaya, Svetlana; Hyde, Sarah; Schofield, Sally; Szeto, John; Woods, Lauren Blair; Yilmaz, Vedat O; Manoharan, Muthiah; Egli, Martin; Charissé, Klaus; Sepp-Lorenzino, Laura; Haslett, Patrick; Fitzgerald, Kevin; Jadhav, Vasant; Maier, Martin A.

Nucleic Acids Res ; 50(12): 6656-6670, 2022 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-35736224

13.

Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.

Humboldt, Adrian; Rami, Fabian; Topp, Franka M; Arnold, Dejana; Göhringer, Daniela; Pallan, Pradeep S; Egli, Martin; Richert, Clemens.

Angew Chem Int Ed Engl ; 63(15): e202319958, 2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38300702

14.

Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.

Pallan, Pradeep S; Lybrand, Terry P; Rozners, Eriks; Abramov, Mikhail; Schepers, Guy; Eremeeva, Elena; Herdewijn, Piet; Egli, Martin.

Biochemistry ; 62(19): 2854-2867, 2023 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-37694722

15.

Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

Matsuda, Shigeo; Bala, Saikat; Liao, Jen-Yu; Datta, Dhrubajyoti; Mikami, Atsushi; Woods, Lauren; Harp, Joel M; Gilbert, Jason A; Bisbe, Anna; Manoharan, Rajar M; Kim, MaryBeth; Theile, Christopher S; Guenther, Dale C; Jiang, Yongfeng; Agarwal, Saket; Maganti, Rajanikanth; Schlegel, Mark K; Zlatev, Ivan; Charisse, Klaus; Rajeev, Kallanthottathil G; Castoreno, Adam; Maier, Martin; Janas, Maja M; Egli, Martin; Chaput, John C; Manoharan, Muthiah.

J Am Chem Soc ; 145(36): 19691-19706, 2023 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-37638886

16.

Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs.

Das, Arnab; Ghosh, Atanu; Kundu, Jayanta; Egli, Martin; Manoharan, Muthiah; Sinha, Surajit.

J Org Chem ; 88(21): 15168-15175, 2023 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-37843026

17.

Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography.

Harp, Joel M; Coates, Leighton; Sullivan, Brendan; Egli, Martin.

Nucleic Acids Res ; 49(8): 4782-4792, 2021 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-33872377

18.

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.

Schlegel, Mark K; Matsuda, Shigeo; Brown, Christopher R; Harp, Joel M; Barry, Joseph D; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charissé, Klaus; Egli, Martin; Maier, Martin A.

Nucleic Acids Res ; 49(19): 10851-10867, 2021 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-34648028

19.

Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

Jahns, Hartmut; Degaonkar, Rohan; Podbevsek, Peter; Gupta, Swati; Bisbe, Anna; Aluri, Krishna; Szeto, John; Kumar, Pawan; LeBlanc, Sarah; Racie, Tim; Brown, Christopher R; Castoreno, Adam; Guenther, Dale C; Jadhav, Vasant; Maier, Martin A; Plavec, Janez; Egli, Martin; Manoharan, Muthiah; Zlatev, Ivan.

Nucleic Acids Res ; 49(18): 10250-10264, 2021 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-34508350

20.

siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.

Akabane-Nakata, Masaaki; Erande, Namrata D; Kumar, Pawan; Degaonkar, Rohan; Gilbert, Jason A; Qin, June; Mendez, Martha; Woods, Lauren Blair; Jiang, Yongfeng; Janas, Maja M; O'Flaherty, Derek K; Zlatev, Ivan; Schlegel, Mark K; Matsuda, Shigeo; Egli, Martin; Manoharan, Muthiah.

Nucleic Acids Res ; 49(5): 2435-2449, 2021 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-33577685

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